| Notch pathway |
+ |
0.00003 |
| VEGFR → ATF/CREB/ELK-SRF signaling |
− |
0.00004 |
| ICAM1 → AP-1/CREB/ELK-SRF signaling |
+ |
0.00005 |
| EGFR/ERBB2 → TP53 signaling |
+ |
0.00006 |
| EGFR/ERBB2 -> HIF1A signaling |
+ |
0.0001 |
| ProstaglandinFR → ATF1/ELK-SRF/CREB signaling |
+ |
0.0001 |
| ThrombinR → AP-1/CREB/ELK-SRF/SP1 signaling |
+ |
0.0001 |
| EphrinR → actin signaling |
+ |
0.0001 |
| DopamineR2 → AP-1/CREB/ELK-SRF signaling |
+ |
0.0001 |
| EndothelinRa → AP-1/CREB signaling |
+ |
0.0001 |
| VasopressinR1 → CREB/ELK-SRF/AP-1/EGR signaling |
+ |
0.0002 |
| EGFR/ERBB2 → CTNNB signaling |
− |
0.0002 |
| Axon Guidance |
+ |
0.0002 |
| EndothelinRb → AP-1/CREB/ELK-SRF signaling |
+ |
0.0002 |
| EGFR → SMAD1 signaling |
+ |
0.0003 |
| EGFR/ERBB3 → MEF/MYOD/NFATC/MYOG signaling |
+ |
0.0003 |
| Focal adhesion regulation |
+ |
0.0005 |
| EGFR → CTNND signaling |
− |
0.0006 |
| ProstaglandinIR → ATF1/ELK-SRF/CREB signaling |
+ |
0.0007 |
| IL13R → STAT6 signaling |
+ |
0.0008 |
| ERBB2/3 → EP300/ETS/ETV/SP1 signaling |
+ |
0.0009 |
| VasopressinR2 → CREB/ELK-SRF/AP-1/EGR signaling |
+ |
0.001 |
| PTAFR → AP-1/ATF1/CREB/ERK-SRF signaling |
+ |
0.001 |
| Mast cell activation |
+ |
0.001 |
| B-cell activation |
+ |
0.001 |
| KIT → MITF signaling |
+ |
0.002 |
| Hairy, Hairy/E(SPL) signaling |
+ |
0.002 |
| FGFR → RUNX2 signaling |
+ |
0.002 |
| EDG3/5 → AP-1/ELK-SRF signaling |
+ |
0.002 |
| IL4R → ELK-SRF/HMGY signaling |
+ |
0.002 |
| T-cell receptor → ATF/CREB signaling |
+ |
0.002 |
| CannabinoidR → AP-1/EGR signalingNK cell activation |
+ |
0.002 |
| NeurotensinR → ELK-SRF/AP-1/EGR signaling |
+ |
0.003 |
| MAP3K signaling |
+ |
0.003 |
| VasopressinR1 → MEF/MYOD/NFATC/MYOG signaling |
+ |
0.003 |
| Actin cytoskeleton regulation |
+ |
0.003 |
| |
|
|
Pathways regulated by cortisol 100 μM
|
Pathway name
|
Change
|
P-value
|
| T-cell activation |
+ |
0.0001 |
| TGFβ receptor → SMAD2/3 signaling |
− |
0.001 |
| GF signaling |
+ |
0.002 |
| GFR → FOXO3A signaling |
+ |
0.002 |
| Endocytosis |
+ |
0.004 |
| |
|
|
Pathways regulated by cortisol 100 nM and 100 μM
|
Pathway name
|
Change
|
P-value Corticosterone 100 nM
|
P-value Corticosterone 100 μM
|
| Hedgehog pathway |
− |
0.005 |
0.0002 |
| GFR → NCOR2 signaling |
+ |
0.0001 |
0.00008 |
| GFR → AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
+ |
0.0005 |
0.0006 |
| Adherens junction regulation |
+ |
0.003 |
0.0003 |
| Guanylate cyclase pathway |
+ |
0.004 |
0.0004 |
| Apoptosis regulation |
+ |
0.003 |
0.003 |
| Gonadotrope cell activation |
+ |
0.005 |
0.00003 |
