Table 4.
Linear regression models Predicting Patient’s Assessment of Own Functioning Inventory (PAOFI) higher-level cognition (HLC) (n = 182)*
| Base model adjusted R 2 = 0.21 | Base model plus BDI-II adjusted R 2 = 0.34 | |||
|---|---|---|---|---|
| Variable | Estimate (95% CI) | P† | Estimate (95% CI) | P† |
| Age | 0.002 (–0.008 to 0.013) | .691 | 0.007 (–0.003 to 0.017) | .145 |
| IQ | –0.003 (–0.012 to 0.007) | .582 | –0.002 (–0.010 to 0.006) | .659 |
| Treatment | ||||
| Radiation | 0.030 (–0.204 to 0.265) | .799 | 0.064 (–0.151 to 0.278) | .558 |
| Chemotherapy | 0.282 (–0.019 to 0.584) | .066 | 0.151 (–0.128 to 0.429) | .286 |
| Chemotherapy & radiation | 0.258 (0.029 to 0.486) | .027 | 0.208 (–0.001 to 0.417) | .051 |
| Hormone therapy | 0.234 (0.047 to 0.421) | .015 | 0.150 (–0.023 to 0.323) | .089 |
| Visual memory§ | 0.135 (0.037 to 0.233) | .007 | 0.101 (0.011 to 0.191) | .029 |
| Psychomotor speed§ | –0.080 (–0.236 to 0.077) | .315 | –0.037 (–0.181 to 0.106) | .611 |
| Executive function§ | –0.126 (–0.271 to 0.019) | .088 | –0.120 (–0.252 to 0.012) | .074 |
| BDI-II|| | ----- | ----- | 0.035 (0.023 to 0.046) | <.001 |
* PAOFI HLC score transformed with log(x+1). BDI-II = Beck Depression Inventory–II; CI = confidence interval.
† Estimates were tested for H0: estimate=0 with a t statistic, controlling for all other variables in the regression model; all tests were two-sided.
§ Scores were calculated by comparing participants’ scores against age-corrected normative scores with a mean of 0 and SD of 1, with positive (ie, > 0) scores representing higher/better performance.
|| BDI-II is calculated without the item pertaining to concentration.