Figure 4. Treatment of HepG2 and MRC5 cells with 2.5 mM 2′AP inhibited AdΔE1b and AdΔE1bΔVA release.

Cells were infected with either AdΔE1b or AdΔE1bΔVA at MOI of 1 GFU/cell for 1 hour prior to treatment with medium containing no drug or 2.5 mM 2′AP. Four days following infection, infected cells combined with the media (total virus) or the media alone (released virus) were harvested. Virus yields were determined by titration in Hep3B cells. Error bars correspond to +/−SD of quadruplicates (*p<0.05, ***p<0.001, one-way ANOVA).