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. 2013 Jun 4;8(6):e64246. doi: 10.1371/journal.pone.0064246

Figure 4. BMT mediates neuroprotection of RGCL neurons in APPswe-PS1ΔE9 and wt mice.

Figure 4

A–C: RGCL neurons were identified using anti-NeuN antibody and visualized with Cy3-conjugated secondary antibody in 13-month-old APPswe-PS1ΔE9 and wt mice. Representative photomicrographs of NeuN+ RGCL neurons in control (A, top) and BMT-recipient (A, bottom) APPswe-PS1ΔE9 mice demonstrate neuroprotective effects of BMT through preservation of RGCL neurons (B) and inner retinal (NFL+RGCL+IPL) thickness (C). D–E: Representative photomicrographs of NeuN+ RGCL neurons in 13-month-old control (D, top) and BMT-recipient (D, bottom) wt mice also demonstrate neuroprotective effects of BMT through preservation of RGCL neurons (E). F: No effects on retinal thickness in wt recipients compared with the wt controls. *P<0.05, n = 6–10, student's t test. Scale bar  = 50 μm.