Table 1. Sample characteristics.
| All patients | MARS Discovery | MARS Replication | Muenster Replication | ||
| N = 894 | N = 398 | N = 249 | N = 247 | P a | |
| Age, mean (SD), y | 48.9 (14.3) | 49.1 (14.4) | 48.0 (13.6) | 49.2 (14.9) | .58 |
| Female gender, No. (%) | 497 (55.6) | 223 (56.0) | 128 (51.4) | 146 (59.1) | .22 |
| Unipolar depression, No. (%) | 780 (87.2) | 345 (86.7) | 231 (92.8) | 204 (82.6) | <.01 |
| HAM-D at admission, mean (SD) | 25.9 (6.6) | 24.4 (6.4) | 27.1 (5.8) | 24.0 (7.2) | <.001 |
| HAM-D at discharge, mean (SD) | 7.6 (6.0) | 9.1 (5.9) | 7.1 (6.2) | 5.8 (5.2) | <.001 |
| Duration of hospital stay (weeks), mean (SD) | 11.5 (9.2) | 11.5 (7.8) | 10.9 (9.0) | 12.0 (11.5) | .45 |
| Response at week 5, No. (%) | 468 (52.3) | 192 (50.1) | 147 (63.4) | 129 (53.1) | .01 |
| Remission at discharge, No. (%) | 581 (65.0) | 204 (60.7) | 172 (72.9) | 202 (81.8) | <.001 |
| Number of previous episodes, mean (SD) | 3.01 (5.4) | 2.84 (5.1) | 3.51 (7.3) | 2.76 (2.8) | .27 |
| Duration of current episode (weeks), mean (SD) | 38.12 (66.0) | 41.37 (71.4) | 32.63 (55.2) | N/A | .11 |
| Psychotic symptoms, No. (%) | 87 (13.6) | 50 (12.6) | 37 (15.4) | N/A | .31 |
| Treatment resistanceb at admission, No. (%) | 94 (16.7) | 54 (15.4) | 40 (18.9) | N/A | .28 |
a
ANOVA and Chi-square, respectively, comparing the different samples. For some variables there are missing data and N does not equal number of total patients. Percentages are based on available data.
b
Treatment resistance was defined as at least 2 antidepressant treatment attempts with an adequate duration and dosage according to Souery et al.
N/A: data not available.