Table 2. Nominally associated BDNF and NTRK2 SNPs in the MARS discovery sample.
| SNP | Gene | Functiona | Minor/major allele | Genotype | MAF | HWE P b | P c (allelic) | P c (genotypic) | ||
| 1/1 | 1/2 | 2/2 | ||||||||
| rs2049048 | BDNF | 5' | T/C | 277 | 110 | 11 | .17 | >.99 | .014 | .008 |
| rs1491850 | BDNF | 5' | C/T | 122 | 189 | 87 | .46 | .42 | .009 | .03 |
| rs4923468 | BDNF | intron | A/C | 388 | 10 | 0 | .01 | >.99 | .01 | >.99 |
| rs2049046 | BDNF | intron | A/T | 133 | 175 | 90 | .45 | .03 | 4.88×10−5 | 4.66×10−4 |
| rs6265 | BDNF | Val66Met | A/G | 242 | 127 | 29 | .23 | .04 | .04 | .07 |
| rs11602246 | BDNF | 3' | G/C | 322 | 69 | 7 | .10 | .17 | .009 | .034 |
| rs11030094 | BDNF | 3' | A/G | 140 | 178 | 80 | .42 | .10 | 1.52×10−4 | 6.05×10−4 |
| rs10868223 | NTRK2 | 5' | T/C | 308 | 82 | 8 | .12 | .35 | .03 | .11 |
| rs1659412 | NTRK2 | 5' | C/T | 320 | 63 | 7 | .10 | .08 | .02 | .08 |
| rs1662695 | NTRK2 | intron | C/T | 301 | 93 | 4 | .13 | .37 | .04 | .11 |
| rs11140778 | NTRK2 | intron | T/A | 247 | 133 | 18 | .21 | >.99 | .004 | .01 |
| rs2277193 | NTRK2 | intron | C/T | 205 | 155 | 35 | .28 | .46 | .02 | .08 |
| rs1948308 | NTRK2 | intron | C/T | 123 | 202 | 73 | .44 | .61 | .008 | .008 |
| rs17418241 | NTRK2 | intron | T/C | 331 | 65 | 2 | .09 | .75 | .04 | .09 |
| rs1387926 | NTRK2 | intron | A/G | 301 | 93 | 3 | .12 | .17 | .047 | .08 |
| rs1490402 | NTRK2 | 3' | G/A | 295 | 98 | 5 | .14 | .40 | .009 | .01 |
a
According to dbSNP build 132.
b
Uncorrected P values for the deviation from Hardy-Weinberg-Equilibrium; note that no P value exceeded the corrected (82 SNPs, Bonferroni) threshold of p<6.1×10−4.
c
Nominal P values for associations with response after 5 weeks (strongest phenotype in the discovery sample).