Table 2. Interleukin concentrations and dates of intraocular treatment in patients with vitreoretinal lymphoma (Cases 1–10).
| Case # | Interleukin-10 concentration (pg/mL) | Interleukin-6 concentration (pg/mL) | Treatment dates/treatment regimens | Eye exam findings |
| Case 1 | 09/08/2010: OD: –;OS: 152.41 | 09/08/2010:OD: –;OS: 6.9 | 09/08/2010: OS: A/C: Deep and quiet; Vitreous: “Some cells trapped between posterior capsule and residual hyaloids face; no cells deeper in vitreous” | |
| 01/20/2010:OS: Dexamethasone 400 mcg/0.1 cc | ||||
| 02/02/2010: OS: Dexamethasone 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | ||||
| 02/03/2010: OD: Dexamethasone 320 mcg/0.8 cc; RTX 1 mg/0.1 cc | ||||
| 05/14/2010: OS: MTX 400 mcg/0.1 cc | ||||
| 09/08/2010: OS: Dexamethasone 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | ||||
| Case 2 | 02/17/2011: OS: 0.56 | 02/17/2011: OS: 211.79 | 02/17/2011: OS: A/C: –; Vitreous: 1+ cell | |
| 08/15/2007: OD: Dexamethasone | ||||
| 10/17/2007: OD: Dexamethasone 400 mcg | ||||
| 12/15/2007: OD: Dexamethasone 400 mcg; MTX 400 mcg | ||||
| Case 3 | 05/20/2010: OD: MTX 400 mcg/0.1cc | |||
| 07/09/2010: OD: 2.04; OS: 72.19 | 07/09/2010: OD: 1.67; OS: 124.21 | 07/09/2010: OU: MTX 400 mcg/0.1 cc | 07/09/2010: OD: A/C: 2+ flare; Vitreous: 2+ cell, dense syneresis, Weiss ring;OS: A/C: 4+ flare; Vitreous: 2+ cell | |
| Case 4 | 08/26/2010: OD: 33.74 | 08/26/2010: OD: 278.75 | 08/26/2010: OD: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | 08/26/2010: No eye exam available |
| Case 5 | 02/14/2011:OD: A/C: Deep and quiet; Vitreous: Trace cells; OS: A/C: Deep and quiet; Vitreous: 1+ cell | |||
| 02/21/2011: OD:–; OS: 0.70 | 02/21/2011: OD:–; OS: 1.67 | 02/21/2011: OS: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | ||
| 03/28/2011: OD: 1.73; OS: 0.56 | 03/28/2011: OD: 20.84; OS: 9.77 | 03/28/2011: OU: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | 03/28/2011: Injection only; No eye exam available | |
| 05/05/2011: OD: 1.72; OS: 0.56 | 05/05/2011: OD: 12.21; OS: 8.63 | 05/5/2011: OU: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | 05/05/2011: OD: A/C: Cataract; Vitreous: Some cells pigmented;OS: A/C: 0.5–1+ cell; Vitreous: 0.5–1+ cell | |
| Case 6 | 02/2007: OD: Corticosteroids | |||
| 08/06/2007: OS: RTX 1.25 mg | ||||
| 02/04/2011: OD: 9.59; OS:– | 02/04/2011: OD: 356.28; OS:– | 02/04/2011: OD: A/C: No cells; Vitreous: Trace cells; OS: A/C: No cells; Vitreous: No cells | ||
| 03/24/2011: OD: –; OS: 0.56 | 03/24/2011: OD: –; OS: 277.38 | 03/24/2011: No eye exam available | ||
| Case 7 | 01/11/2010: OD: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | |||
| 01/19/2010: OD: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | ||||
| 04/8/2010: OS: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | ||||
| 04/22/2010: OD: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1cc | ||||
| 07/06/2010: OD: 10.77; OS: 34.45 | 07/06/2010: OD: 359.07; OS: 960.45 | 07/06/2010: OU: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | 07/06/2010: OD: A/C: Deep and quiet; Vitreous: 2 to 3+ cells; OS: A/C: Deep and quiet; Vitreous: 2+ cells | |
| 08/16/2010: OD: 1.11; OS: 0.56 | 08/16/2010: OD: 85.85; OS: 165.03 | 08/16/2010: OU: RTX 1 mg/0.1 cc | 08/16/2010: OD: A/C: Deep and quiet; Vitreous: 2+ cells (better than before); OS: A/C: Deep and quiet; Vitreous: 1+ cells | |
| 11/03/2010: OD: 3.68; OS: 12.81 | 11/03/2010: OD: 46.03; OS: 96.73 | 11/3/2010: OU: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | 11/03/2010: OD: A/C: Deep and quiet; Vitreous: 2+ cells (not improving);OS: A/C: Deep and quiet; Vitreous: 2+ cells | |
| Case 8 | 01/01/2009: OU: RTX 1 mg/0.1 cc | |||
| 01/26/2009: OU: Ttriamcinolone 4 mg | ||||
| 02/03/2009: OU: RTX 1 mg/0.1 cc | ||||
| 10/11/2010: OD: 9.21; OS:– | 10/11/2010: OD: 10.58; OS:– | 10/11/2010: OD: Dexamethasone 400 mcg/0.1cc; MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | 10/11/2010: No eye exam available | |
| 10/28/2010: OD: 6.54; OS: 0.56 | 10/28/2010: OD: 33.19; OS: 2.93 | 10/28/2010: OU: Dexamethasone 400 mcg/0.1 cc; MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | 10/28/2010 : Injection only; No eye exam available | |
| 11/11/2010: OU MTX 400 mcg/0.1 cc | ||||
| 11/18/2010: OU: RTX 1 mg/0.1 cc | ||||
| 11/29/2010: OU: MTX 400 mcg/0.1 cc | ||||
| 12/20/2010: OD: 0.56; OS: 0.56 | 12/20/2010: OD: 388.67; OS: 1.67 | 12/20/2010: OU: RTX 1 mg/0.1 cc | 12/20/2010: Injection only; No eye exam available | |
| 01/26/2011: OD: 2.12; OS: 0.56 | 01/26/2011: OD: 9.79; OS: 1.94 | 1/26/2011: OU: MTX 400 mcg/0.1 cc | 1/26/2011: OD: A/C : Rare cells; Vitreous: 1+ cells in the mid vitreous, skirt seen; OS: A/C Deep and quiet; Vitreous: Trace pigmented and white cells, post vitreous detachment | |
| 02/22/2011: OU: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | ||||
| 03/16/2011: OD: 0.56; OS: 0.56 | 03/16/2011: OD: 11.22; OS: 2.22 | 03/16/2011: OU : MTX 400; mcg/0.1 cc; RTX 1 mg/0.1 cc | 03/16/2011: OD: A/C: Rare cells; Vitreous: No cells; OS: A/C: Deep and quiet; Vitreous: Pigmented cells; rare white cells | |
| 04/7/2011: OD: 0.56; OS: 0.56 | 04/7/2011: OD: 19.55; OS: 6.32 | 04/07/2011: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | 04/07/2011: OD: A/C: Rare cells; Vitreous: No cells; OS: A/C: Deep and quiet; vitreous: Pigmented cells; rare white cells | |
| Case 9 | 01/18/2010: OD: MTX 400 mcg in 0.08 cc; RTX 1 mg/0.08 cc | |||
| 01/20/2010: OS: MTX 400 mcg/0.08 cc; RTX 1 mg/0.08 cc | ||||
| 01/17/2011: OU: MTX 200 mcg/0.1 cc; RTX 1 mg/0.1 cc | ||||
| 02/09/2011: OD: A/C: Trace to 1+ cells; Vitreous: Post vitreous detachment, 3+ vitreous cells; OS: A/C: Trace cells; Vitreous: Post vitreous detachment, 1+ vitreous debris | ||||
| 02/11/2011: OD: 21.75 | 02/11/2011: OD: 1215 | 02/11/2011: OD: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | ||
| 02/23/2011: OD: 1.48; OS: 2.04 | 02/23/2011: OD: 102.28; OS: 136.78 | 02/23/2011: OU: MTX 400/0.1 cc; RTX 1 mg/0.1 cc | 02/23/2011: Injection only; No eye exam available | |
| 02/28/2011: OS: Ceftazidine 2.25 mg/0.1 cc; Vancomycin 1000 mcg/0.1 cc | ||||
| 03/23/2011: OD: 1.59; OS: 0.56 | 03/23/2011: OD: 33.99; OS: 25.36 | 03/23/2011: OU: MTX 400 mcg/0.1 cc | 03/23/2011: OD: A/C: 2+ cell, 1+ flare, 1+ NS; Vitreous: ?; OS: A/C: 1–2+ cell; 1+ NS; Vitreous: 2+ cell | |
| 04/13/2011: OD: 0.56; OS: O.56 | 04/13/2011: OD: 9.25; OS: 4.91 | 04/13/2011: OU: MTX 400/0.1 cc | 04/13/2011: OD: A/C: 3+ NS; Vitreous: No infiltrates; OS: A/C: 2+ NS; Vitreous: No infiltrates | |
| Case 10 | 02/24/2011: OD: 97.38; OS: 96.85 | 02/24/2011: OD: 14.29; OS: 27.12 | 02/24/2011: No eye exam available | |
| 04/12/2011: OD: 263.9; OS: 151.29 | 04/12/2011: OD: 24.16; OS: 24.22 | 04/12/2011: OD: A/C: Deep and quiet; Vitreous: Significant anterior vitreous cells mixed with residual anterior vitreous sheath; OS: A/C: Deep and quiet; Vitreous: Rare vitreous cells present | ||
| 05/06/2011: OD: 381.44; OS:– | 05/06/2011: OD: 128.3; OS: – | 05/06/2011: OD: MTX 400 mcg/0.1 cc; RTX 1 mg/0.1 cc | 05/06/2011: OD: A/C: Rare white cells; Vitreous: Anterior hyaloids face densely covered with white cells: OS: A/C: No cells, rare white cells; Vitreous: No cells |
A/C Anterior chamber, MTX Methotrexate, OD Oculus dexter, OS Oculus sinister, OU oculus uterque RTX Rituximab.