Table 3. Profiles of patients, interleukin concentrations, and dates of intraocular treatment in patients with uveitis (Cases 11–17).
| Case # | Sex/Age | Comorbidities | VA Initial | VA Recent | Diagnosis | Interleukin -10 concentration (pg/ml) | Interleukin-6 concentration (pg/ml) | Treatment |
| Case 11 | 74-year-old Caucasian female | Shingles involving the left brow area | OD: 20/100 (NI) | OD: 200 E at 8′ | Diagnosed with idiopathic uveitis | 12/21/2010: OD: 0.69 | 12/21/2010: OD: 95.18 | None |
| OS: 20/60 (NI) | OS: 20/25 | PPV at an outside provider (12/2009) demonstrated CD10-positive B cell population | ||||||
| ACE, CBC, CXR, and lysozyme were within normal limits; the patient was HLA-A29 negative; β2 microglobulin was elevated | ||||||||
| Vitreous cytology negative for malignancy from PPV (01/29/2010) | ||||||||
| Case 12 | 91-year-old Caucasian female | Uterine cancer,Skin cancer (BCC, SCC), Leaky heart valve | OD: 20/60+2 (20/50−2) | OD: 20/40−1 (NI) | Diagnosed with idiopathic uveitis | 07/07/2010: OD: <0.56; OS: <0.56 | 07/07/2010: OD: 232.16; OS: 246.41 | None |
| OS: 20/150−1 (20/100−1) | OS: 20/30+1 (NI) | QuantiFERON-TB and β2 microglobulin were elevated | ||||||
| Vitreous cytology negative for malignancy from PPV (07/07/2010); bacterial and fungal cultures of the vitreous also negative | ||||||||
| ACE, Lyme titers, and syphilis IgG and IgM within normal limits | ||||||||
| Case 13 | 81-year-old Caucasian male | Type II diabetes mellitus, chronic obstructive pulmonary disease, bladder cancer, and history of deep vein thrombosis | OD: 20/30 (NI) | OD: 20/25 | Diagnosed with chronic granulomatous panuveitis, likely secondary to fungal infection | 06/02/2010 OS: Triamcinolone | ||
| OS : 200 E at 10′ (NI) | OS: 20/40 | Presented to an outside provider with ocular symptoms; complete uveitis workup was negative except for an elevated ESR of 66 | 07/09/2010 OS: Triamcinolone | |||||
| CXR was significant only for hiatal hernia and changes consistent with chronic obstructive pulmonary disease | 07/22/2010: OS: 2.87 | 07/22/2010: OS: 936.24 | ||||||
| Blood and fungal cultures were negative with no evidence of abscess on CT of chest/abdomen/pelvis. | ||||||||
| Vitreous pathology negative for malignancy, but notable for marked acute inflammatory response with focal granulomas from PPV (08/18/2010) | ||||||||
| AFB smear, Gram stain, and GMS stain were negative. However, retinal sampling was significant for one cluster of Candida albicans | ||||||||
| Case 14 | 73-year-old Caucasian male | Papillary thyroid carcinoma, Sarcoidosis, Type II diabetes mellitus, hypercalcemia, vitamin D deficiency, hypertension, and chronic renal insufficiency | OD: 20/150 (20/100+1) | OD: 20/150 (NI) | Diagnosed with uveitis likely secondary to Sarcoidosis | 08/2010: OS: 4.84 | 08/2010: OS: 805.91 | None |
| OS: 20/400 (20/200) | OS: 20/150 (NI) | Vitreous pathology negative for malignancy but notable for a mixed inflammatory infiltrate consistent with a reactive process from PPV (08/27/10) | ||||||
| Case 15 | 56-year-old Caucasian male | Sarcoidosis | OD: 20/60−2 (NI) | OD: 20/70+2 (NI) | Diagnosed with uveitis likely secondary to Sarcoidosis. | 2/17/2011: OD: MTX 400 mcg/0.1 cc | ||
| OS: 20/25−2 | OS: 20/25−2 | CT of chest positive for enlarged mediastinal and hilar lymph nodes, and levels of ACE were elevated | 04/28/2011: OD: <0.56 | 04/28/2011: OD: 72.73 | 04/28/2011: OD: MTX 400 mcg/0.1 cc | |||
| 05/06/2011OS: <0.56 | 05/06/2011OS: 16.52 | |||||||
| Case 16 | 59-year-old African American male | Sarcoidosis with uveitis diagnosed in 08/2005 | OD: 200 E at 9′ | OD: 20/40 (20/40+2) | Diagnosed with uveitis likely secondary to Sarcoidosis | 08/2006: OD: Triamcinolone | ||
| OS: 20/15−1 | OS: 20/20 | Vitreous pathology negative for malignancy and showed only a mixed inflammatory infiltrate from PPV (10/2006) | 08/2006: OD: Periocular steroid injection | |||||
| 09/2007:OD: Dexamethasone and MTX; 2 mg subconjunctival Dexamethasone | ||||||||
| 03/28/2011: OD: <0.56 | 03/28/2011: OD: 28.33 | 03/28/11: OD: Bevacizumab 1.25 mg/0.05 cc, MTX 400 mcg/0.1 cc | ||||||
| Case 17 | 12-year-old Caucasian female | None | OD: 20/150+1 (NI) | OD: 20/125 | Diagnosed with idiopathic intermediate uveitis | 05/16/2011: OD: <0.56 | 05/16/2011: OD: 114.87 | 05/16/2011: OD: MTX 400 mcg/0.1 cc |
| OS: 20/150+2 (20/60+2) | OS: 20/150 (20/100-1) |
ACE Angiotensin-converting enzyme, AFB Acid-fast bacillus, BCC Basal cell carcinoma, CBC Complete blood count, CT Computed tomography, CXR Chest x-ray, ESR Erythrocyte sedimentation rate, GMS Grocott’s methenamine silver, HLA Human leukocyte antigen, OD Oculus dexter, OS Oculus sinister, OU Oculus uterque, PPV Pars plana vitrectomy, SCC Squamous cell carcinoma, TB Tuberculosis, VA Visual acuity.