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. Author manuscript; available in PMC: 2013 Jun 4.
Published in final edited form as: Front Neuroendocrinol. 2009 May 3;30(2):201–211. doi: 10.1016/j.yfrne.2009.04.007

Fig. 7.

Fig. 7

E2 attenuates ischemia-induced neuroinflammation. A, B: photomicrographs of mouse brain sections stained with a marker for activated microglia (lectin). Mice were ovariectomized and treated with oil or E2 for 1 week prior to MCAO-induced ischemic injury, and collected at 24 h after injury. C: Ischemic injury increased the expression of IL-6 (*, P < 0.0001; oil-treated mice; *, P < 0.005; E2-treated mice) on the injured (ipsilateral) side of the brain compared to the contralateral side. E2 treatment attenuated ischemia-induced production of IL-6 (#P = 0.0271) on the ipsilateral side of the ischemic brain (n = 5–6 per experimental group). All values represent mean ± SEM. Figure reprinted with permission from [84].