Table 2.
MRSI voxel tissue composition and neurometabolites in cingulate subregions in obsessive–compulsive disorder patients before and after brief intensive cognitive-behavioral therapy (CBT) and in age-matched healthy controls. Statistically significant comparisons in boldface.
| Left hemisphere | Right hemisphere | |||||
|---|---|---|---|---|---|---|
|
|
|
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| Control | Pre-CBT | Post-CBT | Control | Pre-CBT | Post-CBT | |
| Pregenual anterior cingulate cortex (pACC) | ||||||
| vol% GM | 72.7 (4.0) | 74.1 (3.2) | 72.7 (4.4) | 71.7 (6.0) | 74.5 (5.2) | 72.9 (5.8) |
| vol% WM | 11.4 (5.3) | 7.0 (4.1) | 7.6 (4.0) | 14.3 (4.3) | 15.3 (4.6) | 12.3 (5.8) |
| tNAA | 8.4 (1.5) | 8.1 (0.7) | 8.6 (1.0) | 8.2 (0.7) | 7.0 (0.4)*** | 7.8 (0.8)† |
| Glx | 14,1 (2.3) | 14.7 (2.5) | 16.5 (2.1) | 13.3 (1.5) | 13.4 (2.7) | 13.8 (1.8) |
| Cr | 5.2 (1.2) | 5.5 (0.9) | 6.0 (0.8) | 5.3 (1.2) | 4.9 (0.5) | 5.4 (0.5) |
| Cho | 1.8 (0.4) | 1.9 (0.4) | 2.0 (0.2) | 1.7 (0.2) | 1.6 (0.3) | 1.8 (0.3) |
| mI | 4.7 (1.0) | 4.8 (1.0) | 5.5 (1.4) | 4.6 (0.6) | 4.3 (1.1) | 4.7 (0.9) |
| Anterior middle cingulated cortex (aMCC)a | ||||||
| vol% GM | 72.6 (5.0) | 74.2 (5.5) | 74.9 (6.9) | 71.8 (6.1) | ||
| vol% WM | 7.1 (4.4) | 12.2 (9.2) | 15.4 (6.3) | 18.2 (10.5) | ||
| tNAA | 8.5 (1.0) | 7.5 (1.4) | 7.9 (0.8) | 8.1 (1.6) | ||
| Glx | 14.6 (2.2) | 11.9 (2.5)†† | 13.3 (2.0) | 12.6 (3.1) | ||
| Cr | 6.1 (0.9) | 5.3 (1.3) | 5.6 (1.0) | 5.6 (1.2) | ||
| Cho | 2.0 (0.3) | 1.8 (0.5) | 1.8 (0.3) | 1.9 (0.4) | ||
| mI | 5.3 (1.2) | 5.1 (1.2) | 4.9 (1.1) | 5.1 (0.8) | ||
MRSI = magnetic resonance spectroscopic imaging, vol% = percent of MRSI voxel volume, GM = gray matter, WM = white matter, tNAA = N-acetyl-aspartate + N-acetyl-aspartyl-glutamate, Glx = glutamate + glutamine, Cr = creatine + phosphocreatine, Cho = choline-containing compounds, mI = myo-inositol. Values are group means (std.) neurometabolite levels corrected for voxel CSF content and expressed in institutional units (IU).
MRSI not acquired for controls in aMCC.
p < 0.05,
p < 0.01 paired T-test of rank-transformed (non-parametric) data, following repeated-measures multivariate analysis of variance.
p < 0.001 independent T-test of rank-transformed data, following omnibus multivariate analysis of covariance. Note that vol% GM and WM refer to proportions of tissue inside the MRSI voxels sampled and not to the total anatomic gray and white matter volumes of the pACC and aMCC.