Table 2.

Globally normalized (regional CMRGlu/ global CMRGlu) PET results before and after ketamine infusion for the MRI-based, a priori ROIs and their relevant control regions

		Baseline Normalized Metabolism		Post-Ketamine Normalized Metabolism								Area
Region		Mean	SD	Mean	SD	t	df	p	d	95% C.I.		Mean	SD
Amygdala	Left	0.839	0.066	0.835	0.105	−0.16	18	0.878	−0.07	−1.06	0.92	176.96	21.85
	Right	0.79	0.065	0.829	0.066	2.21	18	0.04	1.04	0.05	2.03	175.91	21.34
Habenula	Left	1.072	0.174	1.06	0.186	−0.36	18	0.724	−0.17	−1.16	0.82	14.06	5.97
	Right	1.325	0.172	1.247	0.181	−2.48	18	0.023	−1.17	−2.16	−0.18	38.56	11.02
Subgenual ACC	Left	1.091	0.09	1.093	0.072	0.16	18	0.872	0.08	−0.91	1.07	1610.50	285.26
	Right	1.074	0.09	1.063	0.086	−0.77	18	0.452	−0.36	−1.35	0.63	1548.85	329.74
Hippocampus	Left	0.865	0.077	0.874	0.073	0.54	18	0.599	0.25	−0.74	1.24	206.58	22.97
	Right	0.84	0.078	0.85	0.108	0.36	18	0.724	0.17	−0.82	1.16	204.35	29.09
Medial Thalamus	Left	1.291	0.168	1.288	0.151	−0.11	18	0.915	−0.05	−1.04	0.94	137.11	30.64
	Right	1.351	0.164	1.31	0.123	−1.28	18	0.218	−0.6	−1.59	0.39	138.50	29.72

Abbreviations: ACC, anterior cingulate cortex; rCMRGlu, regional cerebral metabolic rate of glucose metabolism; ROI, region of interest.