Table 3.

Results of the voxelwise analysis identifying areas where normalized metabolism increased vs. decreased under ketamine.

Regions of Metabolic Increase under Ketamine
	MNI Coordinate			Peak Voxel		Cluster
Region	X	Y	Z	t-value	Uncorrected p	Extent	Corrected p
R Occipital C	34	−88	−12	5.40	<0.001	4697	<0.001
R Postcentral G	38	−40	64	4.43	<0.001
L Occipital C	−22	−48	−10	4.76	<0.001	3274	0.004
L Inferior Parietal C	−40	−84	−10	4.39	<0.001
L Occipital C	−30	−88	14	4.00	<0.001

Regions of Metabolic Decrease under Ketamine
	MNI Coordinate			Peak Voxel		Cluster
Region	X	Y	Z	t-value	Uncorrected p	Extent	Corrected p
R Insula	40	6	14	5.92	<0.001	2869	0.008
R Ventrolateral PFC	38	40	12	4.38	<0.001
R Dorsolateral PFC	26	30	30	4.32	<0.001
R Habenula	6	−32	4	3.88	<0.001	404	--
R Ventral ACC	20	46	−4	3.49	0.001	347	--
L Amygdala	−16	−8	−14	3.06	0.003	137	--
L Ventral ACC	−10	44	4	2.95	0.004	366	--

Abbreviations: ACC, anterior cingulate cortex; C, cortex; G, gyrus; L, left; MNI, Montreal Neurological Institute coordinates; PFC, prefrontal cortex; R, right.

^*MNI coordinates indicate the distance (in millimeters) from the stereotaxic origin (anterior commissure), with X representing the lateral distance from the origin (positive numbers to the right), Y representing the anterior-posterior dimension (positive numbers anterior), and Z representing the dorsal-ventral dimension (positive numbers dorsal).