Table 1.
Characteristics of the study population
| Characteristic | Controls (N=872) |
Cases (N=1028) |
Unadjusted OR (95% CI) |
P-value |
|---|---|---|---|---|
| Age (years)*, mean (SD) | 60.5 (13.2) | 61.3 (12.8) | 1.05 (0.98, 1.13)‡ | 0.17 |
| Marital status, N (%) | <0.001 | |||
| Missing/unknown | 7 | 29 | - | |
| Married | 698 (80.7) | 736 (73.7) | Reference | |
| Not married | 167 (19.3) | 263 (26.3) | 1.49 (1.20, 1.86) | |
| Race, N (%) | 0.05 | |||
| Missing/unknown | 35 | 120 | - | |
| White | 825 (98.6) | 882 (97.1) | Reference | |
| Other | 12 (1.4) | 26 (2.9) | 2.03 (1.02, 4.04) | |
| Education, N (%) | <0.001 | |||
| Missing | 4 | 83 | - | |
| No high school | 25 (2.9) | 71 (7.5) | 1.95 (1.21, 3.16) | |
| High school | 270 (31.1) | 393 (41.6) | Reference | |
| Some college | 256 (29.5) | 272 (28.8) | 0.73 (0.58, 0.92) | |
| College graduate | 189 (21.8) | 109 (11.5) | 0.40 (0.30, 0.53) | |
| Graduate school | 128 (14.7) | 100 (10.6) | 0.54 (0.40, 0.73) | |
| Smoking status, N (%) | <0.001 | |||
| Missing/unknown | 9 | 84 | - | |
| Never smoked | 552 (64.0) | 583 (61.8) | Reference | |
| Former smoker | 269 (31.2) | 269 (28.5) | 0.95 (0.77, 1.16) | |
| Current smoker | 42 (4.9) | 92 (9.7) | 2.07 (1.41, 3.04) | |
| Age at menarche (years), mean (SD) | 13.0 (1.6) | 12.8 (1.6) | 0.47 (0.26, 0.86)‡ | 0.01 |
| Age at first live birth (years), mean (SD) | 24.1 (4.5) | 23.0 (4.4) | 0.57 (0.46, 0.71)‡ | <0.001 |
| Family history of OVCA, N (%) | 0.01 | |||
| No | 801 (91.9) | 906 (88.1) | Reference | |
| Yes | 71 (8.1) | 122 (11.9) | 1.52 (1.12, 2.07) |
Abbreviations: OR, odds ratio; CI, confidence interval
*
Age for controls is age at study consent and age for cases is age at ovarian tumor diagnosis
‡
Odds ratio is per 10-year increment