Table 3.

Frequency of each Polyphen score among variants listed in the EVS for each gene.

	Polyphen Score
Gene	benign	possibly-damaging	probably-damaging	unknown
KCNQ2	15	4	5	123
KCNQ3	23	8	17	122
SCN2A	27	5	14	167
STXBP1	7	2	6	115
SCN1A	30	21	28	151
SCN1B	10	4	7	42
GABRG2	5	1	2	68
SLC2A1	11	3	7	82
GABRA1	1	0	3	35
EFHC1	19	13	26	63
CHRNA4	20	13	23	106
CHRNB2	7	3	12	46
CHRNA2	14	8	20	63
LGI1	13	2	4	50
KCNMA1	15	7	8	190
SLC2A1	11	3	7	82
CACNA1A	41	15	21	285
KCNA1	14	2	1	30
ATP1A2	16	5	7	181

Gene	Product
KCNQ2	Kv7.2 (K+ channel)
KCNQ3	Kv7.3 (K+ channel)
SCN2A	Nav1.2 (Na+ channel)
STXBP1	Syntaxin binding protein 1
SCN1A	Nav1.1 (Na+ channel)
SCN1B	β1 subunit (Na+ channel)
GABRG2	γ2 subunit (GABAA receptor)
SLC2A1	GLUT1 (glucose transporter type 1)
GABRA1	α1 subunit (GABAA receptor)
EFHC1	EF hand motif protein
CHRNA4	α4subunit (nACh receptor)
CHRNB2	β2 subunit (nACh receptor)
CHRNA2	α2 subunit (nACh receptor)
LGI1	Leucine-rich repeat protein
KCNMA1	KCa1.1 (K+ channel)
SLC2A1	GLUT1 (glucose transporter type 1)
CACNA1A	Cav2.1 (Ca2+ channel)
KCNA1	Kv1.1 (K+ channel)
ATP1A2	Sodium-potassium ATPase