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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Toxicol Pathol. 2012 Nov 2;41(5):10.1177/0192623312464304. doi: 10.1177/0192623312464304

Figure 1.

Figure 1

Reduction of sennosides A and B to pharmacologically-active rhein anthrone by gut microflora and oxidation to rhein (Adapted from Lemli and Lemmons, 1980 and Dressen et al., 1981). Glu=glucose