Table 1.
Final mean body weight, and incidences of hyperplasia in the large intestine in C57BL/6NTac mice in the 5-week feed study of senna.
| Dose (ppm) |
Final weight relative to controls (%) |
Heart Weight | Cecum |
Colon |
Rectum |
|||
|---|---|---|---|---|---|---|---|---|
| Epithelial hyperplasia |
Epithelial hyperplasia |
Epithelial hyperplasia |
||||||
| Male | ||||||||
| 0 | 0.15±0.01 | 0a | 0 | |||||
| 625 | 99 | 0.13±0.00& | 2 | (1.0)b | 0 | |||
| 1,250 | 96 | 0.13±0.01& | 1 | (1.0) | 1 | (1.0) | ||
| 2,500 | 99 | 0.13±0.01& | 1 | (1.0) | 1 | (1.0) | ||
| 5,000 | 99 | 0.13±0.01& | 3 | (1.0) | 4* | (1.3) | ||
| 10,000 | 96 | 0.12±0.00& | 5** | (1.8) | 5** | (2.0) | ||
|
| ||||||||
| Female | ||||||||
| 0 | 0.12±0.00 | 0 | 0 | 0 | ||||
| 625 | 95 | 0.12±0.01 | 0 | 0 | 0 | |||
| 1,250 | 99 | 0.12±0.00 | 0 | 0 | 0 | |||
| 2,500 | 100 | 0.13±0.01 | 2 | (1.0) | 1 | (1.0) | 0 | |
| 5,000 | 94 | 0.13±0.01 | 4* | (1.0) | 5** | (1.4) | 0 | |
| 10,000 | 96 | 0.11±0.00 | 5** | (1.8) | 5** | (3.0) | 3 | (1.0) |
N=5
&
Significantly different (P≤0.01) from the control group by William’s or Dunnett’s test
*
Significantly different (P≤0.05) from the control group by the Fisher exact test
**
P≤0.01
a
Number of animals with lesion
b
Average severity grade of lesions in affected animals: 1=minimal, 2=mild, 3=moderate, 4=marked