Table 2.
Incidences of hyperplasia in the large intestine in heterozygous F1 p53+/− mice in the 40-week feed study of senna.
| Dose (ppm) |
Survivala | Final weight relative to controls (%) |
Cecum | Colon | Rectum | |||
|---|---|---|---|---|---|---|---|---|
| Epithelial hyperplasia |
Epithelial hyperplasia |
Epithelial hyperplasia |
||||||
| Male | ||||||||
| 0 | 25/25 | 0/25b | 0/25 | 0/24 | ||||
| 100 | 24/25 | 101 | 0/25 | 0/25 | 0/25 | |||
| 300 | 25/25 | 104 | 0/25 | 0/25 | 0/25 | |||
| 1,000 | 25/25 | 98 | 0/25 | 0/25 | 0/25 | |||
| 3,000 | 23/25 | 101 | 0/23 | 3/24 | (1.3) | 0/24 | ||
| 10,000 | 24/25 | 95 | 22/25* | (1.4)c | 25/25* | (2.8) | 1/25 | (2.0) |
|
| ||||||||
| Female | ||||||||
| 0 | 23/25 | 0/25 | 0/25 | 0/25 | ||||
| 100 | 23/25 | 99 | 0/25 | 0/25 | 0/25 | |||
| 300 | 23/25 | 96 | 0/25 | 0/25 | 0/25 | |||
| 1,000 | 22/25 | 99 | 0/25 | 0/25 | 0/25 | |||
| 3,000 | 22/25 | 97 | 0/25 | 7/25* | (1.0) | 0/25 | ||
| 10,000 | 24/25 | 93 | 19/25* | (1.3) | 25/25* | (2.7) | 1/25 | (1.0) |
*
Significantly different (P≤0.01) from the control group by the Fisher exact test
a
Number of animals surviving at 40 weeks/number initially in group
b
Number of animals with lesion
c
Average severity grade of lesions in affected animals: 1=minimal, 2=mild, 3=moderate, 4=marked