Table 3.

Incidences of osteosarcoma and hepatocellular adenoma in heterozygous F1p53+/− mice in the 40-week feed study of senna

Dose (ppm)	Osteosarcoma	Hepatocellular Adenoma
Male
0	0a	1c
100	0	0
300	0	5
1,000	3	0
3,000	2	2
10,000	0	1
Female
0	2b	0
100	2	0
300	1	0
1,000	3	0
3,000	0	0
10,000	2	0

N=25

^ahistorical incidence for control groups in 9-month heterozygous F1 p53+/− mouse studies:5/77, range 0-12%

^bhistorical incidence for control groups in 9-month heterozygous F1 p53+/− mouse studies:3/76, range 0-8%

^chistorical incidence for control groups in 9-month heterozygous F1 p53+/− mouse studies:5/76, range 4-11.5%