Table 3.
Adjusted association of fibroblast growth factor 23 (FGF23) and serum phosphate with categories of coronary artery calcium (CAC) and thoracic aorta calcium (TAC) scores using ordinal logistic regression (n=1384)
Model* | Odds ratio for 1 unit increase in CAC category† |
p | Odds ratio for 1 unit increase in TAC category† |
p |
---|---|---|---|---|
Ln FGF23 (per SD‡) | ||||
−Phosphate | 1.05 (0.93–1.20) | 0.43 | 1.07 (0.94–1.21) | 0.33 |
+Phosphate | 1.02 (0.90–1.16) | 0.74 | 1.06 (0.93–1.21) | 0.38 |
Phosphate (per SD‡) | ||||
−FGF23 | 1.29 (1.14–1.46) | <0.01 | 1.12 (0.98–1.27) | 0.10 |
+FGF23 | 1.29 (1.13–1.46) | <0.01 | 1.11 (0.97–1.26) | 0.13 |
adjusted for age, sex, race, Hispanic ethnicity, eGFR, ln-transformed urine albumin-to-creatinine ratio, prior cardiovascular disease, diabetes, hypertension, hypercholesterolemia, smoking, body mass index, corrected serum calcium, ln-transformed PTH and clinical center
+Phosphate is additionally adjusted for serum phosphate
+FGF23 is additionally adjusted for ln-transformed FGF23
Categories defined as: category 1, score=0; category 2, score 1–100; category 3, score 101–400; category 4, score > 400.
SD of Ln FGF23=0.72; SD of phosphate=0.69