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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Autoimmun. 2013 Apr 8;43:44–54. doi: 10.1016/j.jaut.2013.03.002

Figure 7. MRL/lpr Fn14KO mice display improved BBB permeability.

Figure 7

The permeability of the blood brain barrier in individual 10-20 week old female MRL/lpr Fn14KO (n=6) and MRL/lpr Fn14WT (n=6) mice was assessed by calculating the albumin quotient, defined as cerebrospinal fluid (CSF) albumin/serum albumin. Intrathecal IgG synthesis was studied by calculating the IgG index, defined as IgG index = (CSF IgG/serum IgG)/albumin quotient). (A) Albumin quotient. (B) IgG ratio (CSF IgG/serum IgG). (C) IgG index. (D) Anti-dsDNA antibody titers in CSF obtained from 15-23 week old female MRL/lpr Fn14KO and WT mice were measured as described in the Materials and methods. Age and gender matched MRL/+ mice served as controls. Fold change was calculated relative to the OD values in MRL/+ control mice, which were normalized to a value of 1.