Table 3.

Effects of Study Conditions on Peak Change in Physiological and Mood Measures

	Placebo	Caffeine	TH250	TH500	TH1000	F test
Heart Rate (bpm)	0.51 ± 2.03	1.43 ± 3.59	1.42 ± 2.83	2.49 ± 4.82*	3.27 ± 5.25**†	F(4,328)=7.198
Systolic (mmHg)	3.45 ± 5.44	8.01 ± 8.75**	4.04 ± 5.70	5.22 ± 7.08	5.59 ± 7.17	F(4,328)=5.947
Diastolic (mmHg)	3.11 ± 4.22	7.27 ± 7.36**	3.37 ± 5.34	3.84 ± 5.64	3.47 ± 4.92‡	F(4,328)=10.007
DEQ (0–100)
Feel	13.1 ± 2.08	33.35 ± 3.28**	17.65 ± 2.40	20.20 ± 2.82	31.22 ± 3.38**	F(4,320)=12.781
High	5.86 ± 1.52	19.07 ± 2.67**	9.13 ± 1.93	10.39 ± 2.29	11.22 ± 2.02†	F(4,320)=7.611
Like	15.41 ± 2.51	26.40 ± 3.16**	20.96 + 2.82	18.04 + 2.63	19.99 ± 2.85	F(4,320)=4.007
Dislike	14.33 ± 2.61	21.08 ± 2.9	20.86 ± 2.73	23.02 ± 3.1*	31.53 ± 3.57**	F(4,320)=6.788
Want	10.05 ± 1.90	21.71 ± 2.76**	18.72 ± 2.59†	14.2 ± 2.44	12.63 ± 2.25†	F(4,320)=6.366
ARCI
A (0–11)	0.69 ± 1.06	1.47 ± 1.90**	1.03 ± 1.53	0.70 ± 1.29	0.88 ± 1.35	F(4,320)=4.739
BG (0–13)	0.91 ± 1.92	1.73 ± 2.94**	0.78 ± 1.52	0.55 ± 1.15	0.74 ± 1.78†	F(4,320)=5.108
LSD (0–14)	0.84 ± 1.09	1.46 ± 1.99	1.94 ± 2.11	0.84 ± 1.35	1.17 ± 1.62**	F(4,320)=6.752
MBG (0–16)	0.67 ± 1.22	1.54 ± 1.91*	0.96 ± 1.84	0.92 ± 1.69	0.74 ± 1.13†	F(4,320)=2.977
PCAG (0–15)	1.96 ± 2.66	1.20 ± 2.22	2.87 ± 3.02	1.98 ± 2.69	2.30 ± 3.36‡	F(4,320)=4.624
POMS (0–4)
Anger	0.04 ± 0.10	0.05 ± 0.12	0.05 ± 0.16	0.05 ± 0.17	0.05 ± 0.10	F(4,320)=0.160
Anxiety	0.13 ± 0.21	0.30 ± 0.46**	0.15 ± 0.26	0.15 ± 0.23	0.28 ± 0.44**	F(4,320)=5.540
Arousal	0.46 ± 0.78	0.70 ± 0.80*	0.46 ± 0.55	0.43 ± 0.57	0.56 ± 0.89	F(4,320)=2.490
Confusion	0.20 ± 0.31	0.16 ± 0.22	0.14 ± 0.23	0.15 ± 0.27	0.21 ± 0.29	F(4,320)=1.144
Depression	0.04 ± 0.10	0.04 ± 0.15	0.02 ± 0.07	0.04 ± 0.11	0.07 ± 0.16	F(4,320)=1.802
Elation	0.16 ± 0.30	0.22 ± 0.35	0.20 ± 0.30	0.18 ± 0.28	0.16 ± 0.28	F(4,320)=0.821
Fatigue	0.27 ± 0.52	0.12 ± 0.27	0.22 ± 0.37	0.29 ± 0.53	0.35 ± 0.48‡	F(4,320)=3.843
Friendliness	0.12 ± 0.23	0.15 ± 0.23	0.15 ± 0.28	0.14 ± 0.25	0.13 ± 0.29	F(4,320)=0.248
Positive Mood	0.18 ± 0.31	0.25 ± 0.39	0.25 ± 0.34	0.22 ± 0.34	0.19 ± 0.31	F(4,320)=1.086
Vigor	0.18 ± 0.31	0.30 ± 0.45	0.20 ± 0.30	0.20 ± 0.32	0.24 ± 0.44	F(4,320)=1.630

Means (± Stand. Dev.) and F-test statistics. P-values (corrected for multiple comparisons) are highlighted when < 0.05.

^*Statistically significant from placebo p<0.05.

^**Statistically significant from placebo p<0.001.

^†Statistically significant from caffeine p<0.05.

^‡Statistically significant from caffeine p<0.001.