RNA samples isolated from hippocampal tissues of all groups were analyzed for gene expression with custom LDA mouse mitochondrial array. A, Genes that were significantly regulated by S-equol phytoSERM and R/S-equol phytoSERM treatments (red and green, significantly increased or decreased compared to OVX, respectively); B, genes significantly changed in the S-equol phytoSERM treatment group relative to the R/S-equol phytoSERM group (red and green, significantly increased or decreased compared to R/S-equol phytoSERM treatment group, respectively).