Table. 1. Comparative analyses of gene expression regulation by S-equol and R/S-equol phytoSERM treatments.

RNA samples isolated from hippocampal tissues of all groups were analyzed for gene expression with custom LDA mouse mitochondrial array. Significantly changed genes were categorized into 5 different functional groups: lipid metabolism; glucose metabolism and energy sensing; cholesterol trafficking; redox homeostasis; and Aβ production and clearance. Data is presented as relative fold change with the corresponding p value listed for each individual gene.

Functional Group	Gene Symbol	Gene Expression
		S-equol phytoSERM vs OVX		R,S-equol phytoSERM vs OVX		S-equol phytoSERM vs R/S-equol phytoSERM
		Fold Change	P- Value	Fold Change	P- Value	Fold Change	P- Value
Lipid Metabolism	Aacs	2.57	0.038*
	Acaa2	1.23	0.038*
	Echs1					0.77	0.049*
Glucose Metabolism/ Energy Sensing	Ldhb	1.27	0.041*
	Ogdh	1.26	0.024*	1.27	0.003
	Pdha1			1.31	0.027
	Pdhb			1.26	0.032
	Prkaa2	1.38	0.017*
	Opa1	1.16	0.003*			1.07	0.012
Cholesterol Trafficking and Metabolism	Cyp46a1	1.53	0.020*	2.06	0.040*
	Star	1.94	0.033*
	Acba1			1.17	0.008**
	Lact					0.71	0.034*
Redox Homeostasis	Glrx	1.19	0.047*
	Gpx3			0.39	0.027*
	Txn2	1.23	0.022*	1.18	0.047*
	Gsr	0.59	0.049*			0.61	0.034*
Aβ Production and Clearance	Adam17	1.46	0.030*			1.41	0.044*
	Apba1					0.70	0.049*
	Apba3			1.51	0.022*
	Psen2	1.63	0.040*	1.41	0.012*
	Ece2					0.80	0.024*