Skip to main content
. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Dev Comp Immunol. 2013 Apr 6;41(1):33–43. doi: 10.1016/j.dci.2013.03.020

Figure 4. Comparative phylogenetic analysis of immunoglobulin heavy chain framework regions.

Figure 4

The phylogenetic tree was constructed from the amino acid sequence alignment of 88 horse, cow, sheep, pig, human and mouse IGHV gene framework regions. For species other than horse, one sequence was randomly chosen from each gene family. The tree was generated using the neighbor-joining method with p-distances model, and bootstrap values from 1,000 replicates are shown. IGHV clans are noted to the right of the respective cluster. The sequences determined in this study are indicated with the following icons: fetal - open diamond; neonatal - open triangle; foal − x; and adult horse - filled circle.