Table 1.
Characteristics of healthy and polymicrobial infected mice
| Sepsis characteristics | Healthy | 6 h sepsis | 24 h sepsis | P-value |
|---|---|---|---|---|
| WBC (× 103/μl) | 5.45 (4.58-5.9) | 1.85 (1.7-2.18)*** | 0.7 (0.6-1.23)*** | <0.0001 |
| Platelet count (× 103/μl) | 1,238 (1,205-1,339) | 1,002 (844-1,100)*** | 470 (399.8-603.5)*** | <0.0001 |
| LDH (U/l) | 335 (296-375.5) | 462 (388-585)** | 545.5 (456.3-671.3)*** | <0.0001 |
| ASAT (U/l) | 41.5 (38-47.5) | 77.5 (64.25-108.3)*** | 123.5 (96.25-157)*** | <0.0001 |
| ALAT (U/l) | 20.5 (19-22.75) | 32.5 (26.25-45)** | 33.5 (24.25-46.25)** | <0.001 |
| Bacterial burden kidneys (CFU) | 0 (0-275) | 7,650 (575-24,350) | <0.0001 | |
| Bacterial burden blood (CFU) | 15 (0-65) | 20,800 (1,050-68,900) | <0.001 |
Data are presented as median ± interquartile range. Investigated clinical chemistries from plasma samples of healthy controls (n = 16 to 20) and of polymicrobial infected mice 6 h (n = 16 to 20) and 24 h (n = 16 to 20) post-sepsis induction as well as bacterial burden from whole blood (6 and 24 h; n = 24). Statistically significant difference compared with healthy controls by ANOVA: **P ≤ 0.01, *** P ≤ 0.001. ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; CFU, colony forming units; LDH, lactate dehydrogenase; WBC, white blood cells.