Figure 2.
Changes in brain metabolism, brain tissue oxygen tension and bsas during is-trials. Average time course of MD parameters before and after the IS-trial (Panel A-B). Panel C shows average time course of PbtO2 at baseline (time = 0) during the trial (grey-square) and over two hours following restart of sedation and analgesics (x-axis). Panel D gives the percentage of trials with PbtO2 < 20 mmHg in both groups. In Panel E the bedside shivering scale of both groups is shown. Groups are reflected as patients who completed the trial (empty square) and patients who developed a failure criteria (filled square). Error bars represent means and one standard error of n = 54 individual trials. P-value is given for significant differences (** = P < 0.001, * = P < 0.05). BSAS, bedside shivering assessment scale; LPR, lactate-pyruvate ratio; PbtO2, brain tissue oxygen tension.