Table 2.
Differences between survivors and non-survivors at the time first organ failure is diagnosed.
| Survivors (n = 66) |
Non-survivors (n = 93) |
|
|---|---|---|
| Predisposition | ||
| Age | 51.1 ± 1.1 | 52.5 ± 0.9 |
| Gender (M/F) | 47/19 | 72/21 |
| Aetiology alcohol N (%) | 45 (68) | 70 (75) |
| PT (sec) | 15.9 ± 0.4*** | 20.7 ± 0.6 |
| INR | 1.54 ± 0.04** | 1.91 ± 0.06 |
| aPTT (sec) | 49.9 ± 2.0*** | 65.5 ± 3.4 |
| Bilirubin (umol/L) | 190.6 ± 20.0*** | 331.2 ± 25.4 |
| Albumin (g/L) | 27.3 ± 0.9** | 24.8 ± 0.7 |
| Creatinine (umol/L) | 114.8 ± 13.3*** | 170.5 ± 16.9 |
| Child | 10.1 ± 0.2*** | 12.1 ± 0.2 |
| MELD | 12.0 ± 1.0*** | 19.6 ± 1.1 |
| Hospitalisation within last 6 months N (%) | 15 (23) | 55 (59) |
| Injury | ||
| Infection N (%) | 28 (42) | 54 (58) |
| Variceal bleed N (%) | 22 (33) | 23 (24) |
| Alcohol binge N (%) | 40 (60) | 47 (51) |
| Dehydration N (%) | 6 (9) | 15 (16) |
| Drugs N (%) | 2 (3) | 1 (1) |
| Response | ||
| SIRS N (%) | 25 (38) | 46 (49) |
| Infection N (%) | 12 (18)** | 38 (41) |
| Organ failure | ||
| Inotrope N (%) | 3 (5)*** | 44 (47) |
| Renal failure N (%) | 12 (18)*** | 53 (57) |
| Haemofiltration N (%) | 7 (11)*** | 38 (41) |
| Mechanical ventilation N (%) | 10 (15)*** | 45 (48) |
| Hepatic encephalopathy | 39 (59) | 52 (56) |
| Hyperbilirubinemia > 340 umol/l | 10 (15)*** | 38 (41) |
| Severe coagulopathy | 1 (2)** | 15 (18) |
| APACHEII | 10.9 ± 0.8* | 15.1 ± 0.8 |
| SOFA | 6.7 ± 0.3** | 9.4 ± 0.3 |
*P < 0.05; **P < 0.005; ***P < 0.001; data expressed as mean (SEM). APACHE II, Acute Physiology, Age and Chronic Health Evaluation; aPTT, activated partial thromboplastin time; INR, international normalised ratio; MELD, Model for End-Stage Liver Disease; PT, prothrombin time; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sepsis Organ Failure Assessment.