Table 3.
Univariate and multivariable logistic regression analysis of mortality at the time first organ failure is diagnosed.
| Univariate | Multivariable | ||||
|---|---|---|---|---|---|
| Risk factor | N | Crude OR (95% CI) |
P value | Adjusted OR (95% CI) |
P value |
| Predisposition | |||||
| Age | 159 | 1.02 (0.98, 1.05) | 0.324 | ||
| Gender (M/F) | 159 | 0.72 (0.35, 1.48) | 0.375 | ||
| Aetiology alcohol | 159 | 1.42 (0.71, 2.86) | 0.325 | ||
| PT (sec) | 128 | 1.44 (1.23, 1.68) | < 0.0001 | ||
| INR (per unit) | 159 | 8.94 (3.12, 25.66) | < 0.0001 | 6.43 (1.82, 22.71) | 0.004 |
| aPTT (sec) | 132 | 1.04 (1.01, 1.06) | 0.001 | ||
| Bilirubin (per 10 umol/L) | 158 | 1.03 (1.02, 1.05) | < 0.0001 | 1.04 (1.02, 1.07) | 0.001 |
| Albumin (g/L) | 145 | 0.94 (0.89, 0.99) | 0.027 | ||
| Creatinine (per 10 umol/L) |
148 | 1.04 (1.00, 1.07) | 0.028 | ||
| Child score | 152 | 1.91 (1.51, 2.41) | < 0.0001 | ||
| MELD score | 146 | 1.09 (1.05, 1.14) | < 0.0001 | ||
| Hospitalisation within last 6 months | 159 | 4.92 (2.42, 10.00) | < 0.0001 | 4.97 (1.89, 13.09) | 0.001 |
| Injury | |||||
| Infection | 159 | 1.88 (0.99, 3.56) | 0.053 | ||
| Variceal bleed | 159 | 0.66 (0.33, 1.32) | 0.237 | ||
| Alcohol binge | 159 | 0.66 (0.35, 1.26) | 0.210 | ||
| Dehydration | 159 | 1.92 (0.70, 5.25) | 0.202 | ||
| Drugs | 159 | 0.35 (0.03, 3.92) | 0.393 | ||
| Response | |||||
| SIRS score | 158 | 1.38 (1.00, 1.91) | 0.051 | ||
| Infection | 152 | 3.05 (1.43, 6.49) | 0.004 | ||
| Organ failure | |||||
| Inotrope | 152 | 18.81 (5.49, 64.45) | < 0.0001 | 14.70 (3.18, 68.03) | 0.001 |
| Renal failure | 153 | 6.09 (2.86, 12.97) | < 0.0001 | 3.46 (1.18, 10.12) | 0.023 |
| Haemofiltration | 152 | 5.96 (2.45, 14.53) | < 0.0001 | ||
| Mechanical ventilation | 152 | 5.42 (2.45, 11.98) | < 0.0001 | ||
| Hepatic encephalopathy | 159 | 0.88 (0.46, 1.66) | 0.690 | ||
| Hyperbilirubinemia > 340 umol/l | 159 | 3.87 (1.76, 8.52) | 0.001 | ||
| Severe coagulopathy | 144 | 13.24 (1.70, 103.20) | 0.014 | ||
| APACHE II score | 114 | 1.12 (1.04, 1.20) | 0.002 | ||
| SOFA score | 153 | 1.51 (1.29, 1.77) | < 0.0001 | ||
Due to different amount of missing data and correlations among predictors, stepwise selection was done manually to build the multivariable model. 151 observations were included in the final multivariable analysis. The scores (Child, MELD, SOFA, APACHE II) were not incorporated into the multivariable analysis. APACHE II, Acute Physiology, Age and Chronic Health Evaluation; aPTT, activated partial thromboplastin time; CI, confidence interval; INR, international normalised ratio; MELD, Model for End-Stage Liver Disease; OR, odds ratio; PT, prothrombin time; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sepsis Organ Failure Assessment.