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Metabolism of essential fatty acids, their role in inflammation, and factors that influence desaturases. AA, arachidonic acid; ALA, α-linolenic acid; COX, cyclooxygenase; DGLA, dihomo-γ-linolenic acid; DHA, docosahexaenoic acid; eNO, endothelial nitric oxide; EPA, eicosapentaenoic acid; GLA, γ-linolenic acid; HMGB1, high-mobility group box 1; LA, linolenic acid; LOX, lipoxygenase; LT, leukotriene; NPD, neuroprotectin; PG, prostaglandin; ROS, reactive oxygen species; TX, thromboxane.
