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. Author manuscript; available in PMC: 2013 Jun 5.
Published in final edited form as: Arch Neurol. 2012 Apr;69(4):490–499. doi: 10.1001/archneurol.2011.2167

Figure 1.

Figure 1

Pattern of myelin loss within the dentate nucleus in Kearns-Sayre syndrome (KSS). There was an apparent loss of myelin-associated glycoprotein (MAG) (A-C) and 2′,3′-cyclic nucleotide phosphodiesterase (CNPase) (D-F) compared with myelin oligodendrocyte glycoprotein (MOG) (G-I) and myelin basic protein (MBP) (J-L) immunoreactivity within the dentate nucleus white matter (KSS patient 1). G-I, The loss of MOG was much less striking than MAG loss in serial sections. At high magnification (original magnification ×63), the loss of MAG (A-C) and CNPase (D-F) in KSS was notable compared with corresponding control tissue. In contrast, the difference in MOG (G-I) and MBP (J-L) immunoreactivity between KSS and control tissue was subtle, if at all. Scale bar represents 12 μm.