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. 2013 May 15;27(10):1115–1131. doi: 10.1101/gad.198630.112

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Figure 6. — Tsc2-deficient tumors exhibit a correlation between markers of hypoxia, mTORC1 signaling, UPR activation, and apoptosis. (A) Representative kidneys from Tsc2^+/+ and Tsc2^+/− 3-mo-old mice treated with ENU at embryonic day 14.5 (E14.5). (B) H&E sections of kidney adenomas (panel a) and cysts (panels b,c) from 3-mo-old Tsc2^+/− mice treated with ENU at E14.5. (C) Sequential paraffin-embedded tumor sections from a representative murine Tsc2^−/− kidney adenomatous cyst were assayed for TUNEL positive cells (black arrow). (D) Kidney cysts were dissected from 18-mo-old untreated Tsc2^+/− mice and kidney tissue from age-matched controls (six tumor and three control samples). RNA was isolated and analyzed for the levels of Pdk1, Ho-1, Xbp1_s, Xbp1_u, Dgat, Ero1, and CHOP transcripts. (*) P < 0.01; (**) P < 0.05. (E) Representative electron micrographs are shown for Tsc2^+/+ kidney and Tsc2^−/− kidney cysts. White arrows indicate the ER.