Table 2.

Genotype distributions and allele frequencies of OPN polymorphisms in OA and control subjects

OPN polymorphism	Allele frequency	OA patients, n	%	Controls, n	%	Global P-value	Adjusted OR	95% CI		Adjusted P-value
-156/G/GG	GG	203	27.07	213	26.83	0.557	1
	GGG	352	46.93	391	49.24		0.956	0.732	1.276	0.701
	GGGG	195	26.00	190	23.93		1.787	0.887	1.552	0.674
	G	758	50.53	817	51.45	0.318	1
	GG	742	49.47	771	48.55		1.038	0.785	1.267	0.658
-443C/T	CC	167	22.27	119	14.99	< 0.001	1
	CT	384	51.20	405	51.01		0.763	0.457	0.998	0.003
	TT	199	26.53	270	34.01		0.525	0.392	0.872	< 0.001
	C	718	47.87	643	40.49	0.018	1
	T	782	52.13	945	59.51		0.689	0.575	0.896	< 0.001
-66T/G	TT	188	25.07	153	19.27	0.013	1
	TG	369	49.20	402	50.63		0.738	0.516	0.988	0.035
	GG	193	25.73	239	30.10		0.657	0.494	0.874	0.017
	T	745	49.67	708	44.58	0.009	1
	G	755	50.33	880	55.42		0.876	0.765	0.876	0.011

OPN, osteopontin; OA, osteoarthritis; OR, odds ratio.