Table 2.

Serial carotid intima-media thickness measurements in pediatric-onset systemic lupus erythematosus

Source	Number (% female)	Age (years)	Disease duration (years)	Frequency of CIMT assessment	CIMT progression (mm/year)
Huang and colleagues [20]	76 (90%)	15.0 ± 3.5	2.7 ± 2.5	Baseline and every 6 monthsa	0.0016 ± 0.0016b
Schanberg and colleagues [26]	108 (82%)c	15.8 ± 2.5	2.5 ± 2.3	Baseline, 6, 12, 24 and 36 months	0.0024 (0.0007, 0.0040)d
	113 (84%)e	15.7 ± 2.8	2.7 ± 2.4		0.0010 (-0.0006, 0.0026)d

Values presented as mean ± standard deviation, unless otherwise specified. CIMT, carotid intima-media thickness. ^aMean number of CIMT assessments performed: 4.6 ± 1.6. ^bMean ± standard error; CIMT adjusted for age at diagnosis. ^cSubjects were in the placebo arm of the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial. ^dCIMT presented as mean (95% confidence interval). ^eSubjects were in the atorvastatin arm of the APPLE trial.