Table 2.

Geometric mean level (GML; 95% CI) in milligrams per liter and percentage of patients with protective antibody levels for both 23F and 6B in different treatment groups at vaccination, at 4 to 6 weeks, and at 1

	RA on methotrexate	RA on anti-TNF as monotherapy	RA on anti-TNF+MTX	SpA on anti-TNF as monotherapy	SpA on anti-TNF+MTX	SpA on NSAID/analgesics
At vaccination
Patient number (n)	85	79	89	83	83	86
GML (95% CI) for 23F	0.7 (0.5-1.1)	0.6 (0.4-0.8)	0.7 (0.5-0.9)	0.7 (0.5-0.9)	0.8 (0.6-1.2)	0.97 (0.7-1.4)
GML (95% CI) for 6B	2.0 (1.4-2.8)	1.4 (0.9-2.0)	1.5 (1.1-2.9)	1.5 (1.1-2.1)	1.7 (1.1-2.5)	2.9 (2.1-4.0)
4 to 6 weeks of follow-up
GML (95% CI) for 23F	1.9 (1.3-2.6)	1.9 (1.3-2.7)	1.4 (1.1-1.9)	3.1 (2.2-4.5)	2.5 (1.8-3.5)	6.4 (4.5-9.1)
GML (95% CI) for 6B	3.5 (2.5-4.9)	3.6 (2.5-5.3)	2.3 (1.7-3.2)	4.8 (3.3-6.9)	3.0 (22.1-4.4)	9.5 (6.7-13.6)
Percentage of patients with protective antibody levels for both 23F and 6B	67%	58%	52%	78%	65%	84%
1.5-year follow-up
Patient number (n)	57	50	56	47	49	43
GML (95% CI) for 23F	0.6 (0.4-0.8)	0.5 (0.3-0.8)	0.4 (0.3-0.5)	1.0 (0.6-1.6)	0.8 (0.5-1.3)	2.0 (1.3-3.0)
GML (95% CI) for 6B	1.2 (0.7-1.9)	1.0 (0.6-1.7)	0.6 (0.4-1.0)	1.4 (0.9-2.1)	1.0 (0.6-1.6)	2.8 (1.7-4.6)
Percentage of patients with protective antibody levels for both 23F and 6B	40%	32%	20%	60%	49%	70%
1.5-year follow-up/4 to 6 weeks of follow-up
Relative ratio of protective antibody levels	0.61	0.55	0.38	0.77	0.75	0.84