Table 4.

Unadjusted HR estimates of the treatment by marker effects

		RFS			OS
		HR	95% CI	TxM (HR)	HR	95% CI	TxM (HR)
TIMP-1	Negative (n = 167; 58%)	0.642	0.377 to 1.091	1.311	0.784	0.447 to 1.376	1.667
	Positive (n = 121; 42%)	0.478	0.247 to 0.927	(0.562 to 3.056)	0.461	0.213 to 1.002	(0.641 to 4.339)
2T Profile	Responsive (n = 183; 66.8%)	0.613	0.365 to 1.029	1.022	0.450	0.188 to 1.080	1.579
	Non-responsive (n = 91; 33.2%)	0.582	0.277 to 1.221	(0.415 to 2.520)	0.739	0.428 to 1.277	(0.565 to 4.411)
HT Profile	Responsive (n = 181; 66.1%)	0.658	0.400 to 1.082	0.902	0.783	0.464 to 1.320	0.577
	Non-responsive (n = 93; 33.9%)	0.531	0.235 to 1.200	(0.347 to 2.346)	0.384	0.141 to 1.046	(0.186 to 1.788)