Table 2.
Summary of performance characteristics of urinary angiotensinogen as a predictor of outcomes among acute kidney injury patients
| Outcome | AUC a | Cutoff (ng/mg) | Sensitivity | Specificity |
|---|---|---|---|---|
| RRT or deathb | 0.73 (0.58 to 0.88) |
Best: > 34.76 | 78.3% | 54.6% |
| Max LR+: > 230.0 | 43.5% | 95.5% | ||
| Min LR-: ≤ 7.58 | 95.7% | 31.8% | ||
| LOSc | 0.77 (0.63 to 0.92) |
Best: > 59.61 | 60.6% | 83.3% |
| Max LR+: > 123.5 | 43.5% | 95.5% | ||
| Min LR-: ≤ 3.31 | 97.1% | 25.0% | ||
| Worsening AKId | 0.77 (0.63 to 0.91) |
Best: > 34.76 | 87.0% | 63.6% |
| Max LR+: > 230.0 | 39.1% | 90.9% | ||
| Min LR-: ≤ 21.24 | 95.7% | 59.1% | ||
aAUC, area under the receiver operator characteristic curve; bRRT, renal replacement therapy; cLOS, length of hospital stay (days after sample collection); dworsening acute kidney injury (AKI) defined as an increase in serum creatinine > 0.3 mg/dL after sample collection or initiation of RRT; LR, likelihood ratio; Max, maximum; Min, minimum.