Table 4.
Fluid and antibiotic dosage among different groups of BMI
|
Intervention
a
mean (SD) |
< 18.50 Number = 196 |
18.50 to 4.99 Number = 1,020 |
25.0 to 29.99 Number = 816 |
30.0 to 39.99 Number = 680 |
≥ 40 Number = 170 |
P value | Adjusted P value b | Adjusted P value c |
|
|---|---|---|---|---|---|---|---|---|---|
| Crystalloid | Number = 1,506 (52.3%) | Number = 96 (49.0) | Number = 537 (52.6) | Number = 439 (53.8) | Number = 346 (50.9) | Number = 88 (51.8) | |||
| Total (ml) | 2,580.3 (1,874.9) | 2,690.0 (2,050.2) | 2,861.7 (2,445.1) | 2,537.4 (2,032.0) | 2,602.3 (1,919.1) | 0.30 | 0.76 | 0.59 | |
| Dose per kg of actual body weight (ml/kg) | 55.0 (40.1) | 43.2 (33.4) | 37.1 (30.8) | 27.7 (22.0) | 21.4 (16.8) | < 0.001 | < 0.001 | < 0.001 | |
| Colloid | Number = 1,506 (52.3%) | Number = 96 (49.0) | Number = 537 (52.6) | Number = 439 (53.8) | Number = 346 (50.9) | Number = 88 (51.8) | |||
| Total (ml) | 656.8 (864.8) | 509.8 (781.0) | 593.5 (788.7) | 705.5 (2,824.5) | 538.9 (939.8) | 0.44 | 0.79 | 0.31 | |
| Dose per kg of actual body weight (ml/kg) | 14.3 (19.3) | 8.2 (12.7) | 7.7 (10.2) | 8.5 (44.2) | 4.3 (7.2) | 0.06 | 0.02 | < 0.001 | |
| Packed red blood cell | Number = 94 (3.3%) | Number = 5 (2.6) | Number = 29 (2.8) | Number = 31(3.8) | Number = 24 (3.5) | Number = 5 (2.9) | |||
| Total (ml) | 462.0 (180.7) | 601.0 (630.3) | 522.5 (243.2) | 502.0 (250.0) | 961.2 (781.5) | 0.26 | 0.68 | 0.79 | |
| Dose per kg of actual body weight (ml/kg) | 9.6 (4.1) | 9.7 (10.8) | 6.8 (3.1) | 5.4 (3.0) | 7.3 (5.5) | 0.18 | 0.02 | 0.53 | |
| Fresh frozen plasma | Number 70 (2.4%) | Number = 4 (2.0) | Number = 22 (2.2) | Number = 21(2.6) | Number = 18 (2.6) | Number = 5 (2.9) | |||
| Total (ml) | 737.5 (715.7) | 498.7 (224.4) | 600.0 (336.9) | 526.8 (333.1) | 1,260.0 (1,34.9) | 0.01 | 0.005 | 0.02 | |
| Dose per kg of actual body weight (ml/kg) | 18.9 (20.8) | 8.2 (4.4) | 7.8 (4.7) | 5.8 (3.7) | 10.4 (8.4) | 0.01 | 0.77 | 0.62 | |
| Piperacillin/tazo-bactam | Number = 564 (19.6%) | Number = 46 (23.5) | Number = 214 (21.0) | Number = 145 (17.8) | Number = 129 (19.0) | Number = 30 (17.6) | |||
| Total dose (mg) | 10,214.7 (3,216.3) | 10,714.8 (3,155.2) | 11,005.3 (3,074.6) | 10,754.8 (3,264.7) | 10,766.7 (2,699.9) | 0.68 | 0.06 | ||
| Dose per kg of dosing body weight | 183.5 (66.7) | 174.8 (59.9) | 168.3 (56.1) | 161.0 (59.9) | 133.2 (40.2) | 0.001 | < 0.001 | ||
| Cefotaxime | Number = 772 (26.8%) | Number = 51 (26.0) | Number = 297 (29.1) | Number = 212 (26.0) | Number = 173 (25.4) | Number = 39 (22.9) | |||
| Total dose (mg) | 3,549.0 (1,932.0) | 3,477.8 (1,821.8) | 3,787.7 (1,857.4) | 3,359.8 (1,531.0) | 4,256.4 (2,220.9) | 0.02 | 0.006 | ||
| Dose per kg of dosing body weight | 62.1 (38.5) | 56.5 (31.6) | 57.2 (28.7) | 49.7 (24.4) | 53.5 (30.2) | 0.04 | 0.32 | ||
| Imipenem | Number = 242 (8.4%) | Number = 15 (7.7) | Number = 79 (7.7) | Number = 75 (9.2) | Number = 56 (8.2) | Number = 17 (10.0) | |||
| Total dose (mg) | 1,566.7 (457.7) | 1,665.2 (597.5) | 1,693.3 (700.6) | 1,705.4 (796.5) | 1,426.5 (584.7) | 0.60 | 0.36 | ||
| Dose per kg of dosing body weight | 25.9 (9.0) | 27.0 (9.9) | 24.9 (10.3) | 24.2 (13.1) | 7.3 (54.6) | 0.002 | < 0.001 | ||
| Gentamycin | Number = 511 (17.7%) | Number = 33 (16.8) | Number = 184 (18.0) | Number = 149 (18.3) | Number = 122 (17.9) | Number = 23 (13.5) | |||
| Total dose (mg) | 173.3 (82.4) | 219.9 (241.4) | 256.7 (229.4) | 239.4 (118.3) | 262.0 (121.9) | 0.18 | 0.01 | ||
| Dose per kg of dosing body weight | 3.2 (1.5) | 3.6 (4.0) | 3.8 (3.2) | 3.3 (1.7) | 3.2 (1.6) | 0.63 | 0.96 | ||
| Meropenem | Number = 277 (9.6%) | Number = 19 (9.7) | Number = 83 (8.1) | Number = 85 (10.4) | Number = 70 (10.3) | Number = 20 (11.8) | |||
| Total dose (mg) | 2,342.1 (1,179.1) | 1,807.2 (791.8) | 1,865.9 (990.6) | 1,678.6 (920.9) | 2,050.0 (916.2) | 0.07 | 0.75 | ||
| Dose per kg of dosing body weight | 40.7 (19.4) | 29.8 (15.0) | 28.8 (15.7) | 25.0 (15.5) | 26.1 (11.3) | 0.003 | 0.01 | ||
| Levofloxacin | Number = 301 (10.4%) | Number = 28 (14.3) | Number = 110 (10.8) | Number = 81 (9.9) | Number = 62 (9.1) | Number = 20 (11.8) | |||
| Total dose (mg) | 426.8 (118.2) | 489.8 (164.3) | 488.0 (205.8) | 441.5 (251.8) | 462.5 (91.6) | 0.32 | 0.82 | ||
| Dose per kg of dosing body weight | 8.0 (2.5) | 8.0 (3.1) | 7.1 (2.8) | 6.2 (4.4) | 5.3 (1.3) | < 0.001 | < 0.001 | ||
| Vancomycin | Number = 771 (26.8%) | Number = 53 (27.0) | Number = 261(25.6) | Number = 209 (25.6) | Number = 194 (28.5) | Number = 54 (32.1) | |||
| Total dose (mg) | 1,292.5 (521.6) | 1,421.2 (630.3) | 1,380.4 (578.4) | 1,353.1 (623.0) | 1,441.4 (680.6) | 0.54 | 0.20 | ||
| Dose per kg of dosing body weight | 28.5 (13.7) | 22.9 (11.2) | 17.9 (7.6) | 14.8 (7.2) | 11.3 (5.8) | < 0.001 | < 0.001 | ||
| Ciprofloxacin | Number = 634 (22.0%) | Number = 39 (19.9) | Number = 218 (21.4) | Number = 186 (22.8) | Number = 165 (24.3) | Number = 26 (15.3) | |||
| Total dose (mg) | 682.9 (280.3) | 674.4 (237.0) | 671.4 (255.8) | 670.3 (363.1) | 682.7 (210.2) | 1.0 | 0.13 | ||
| Dose per kg of dosing body weight | 13.0 (5.2) | 10.9 (4.4) | 10.1 (4.1) | 9.1 (5.0) | 7.6 (2.6) | < 0.001 | < 0.001 | ||
| Ampicillin | Number = 340 (11.8%) | Number = 19 (9.7) | Number = 122 (12.0) | Number = 115 (14.1) | Number = 70 (10.3) | Number = 14 (8.2) | |||
| Total dose (mg) | 4,106.6 (1,788.6) | 4,002.3 (1,940.8) | 4,326.1 (2,019.7) | 4,072.1 (1,64.0) | 5,071.4 (2,302.7) | 0.31 | 0.01 | ||
| Dose per kg of dosing body weight | 71.8 (38.4) | 64.8 (32.2) | 66.5 (33.0) | 61.3 (31.0) | 67.0 (36.3) | 0.74 | 0.85 | ||
| Amphotericin B | Number = 102 (3.5%) | Number = 5 (2.6) | Number = 34 (3.3) | Number = 36 (0.4) | Number = 25 (3.7) | Number = 2 (1.2) | |||
| Total dose (mg) | 3,897.2 (4,330.8) | 5,531.1 (3,998.5) | 6,866.2 (5,977.6) | 5,079.2 (4,933.2) | 10,520.0 (10,521.7) | 0.35 | 0.53 | ||
| Dose per kg of dosing body weight | 85.4 (91.9) | 84.9 (59.7) | 90.9 (80.2) | 54.3 (52.4) | 83.5 (86.7) | 0.33 | 0.15 | ||
| Ceftazidime | Number = 292 (10.1%) | Number = 25 (1.3) | Number = 106 (10.4) | Number = 89 (10.9) | Number = 58 (8.5) | Number = 14 (8.2) | |||
| Total dose (mg) | 2,710.0 (1,154.0) | 3,547.2 (1,867.7) | 2,995.3 (1,691.5) | 3,025.9 (1,590.6) | 3,285.7 (1,683.8) | 0.08 | 0.10 | ||
| Dose per kg of dosing body weight | 47.2 (18.3) | 57.5 (30.7) | 46.9 (28.0) | 43.9 (23.6) | 42.7 (17.7) | 0.01 | 0.48 | ||
| Ceftriaxone | Number = 232 (8.0%) | Number = 12 (6.1) | Number = 77 (7.5) | Number = 67 (7.6) | Number = 58 (8.5) | Number = 18 (10.6) | |||
| Total dose (mg) | 1,666.7 (492.4) | 1,655.8 (1,052.1) | 1,776.1 (884.6) | 1,672.4 (943.8) | 1,611.1 (607.7) | 0.93 | 0.77 | ||
| Dose per kg of dosing body weight | 31.9 (10.2) | 26.1 (14.4) | 27.5 (12.7) | 24.6 (13.7) | 21.5 (8.7) | 0.20 | 0.02 | ||
| Cefuroxime | Number = 772 (26.8%) | Number = 19 (9.7) | Number = 74 (7.3) | Number = 68 (8.3) | Number = 55 (8.1) | Number = 11(6.5) | |||
| Total dose (mg) | 2,578.9 (920.6) | 2,171.8 (1,063.2) | 2,216.9 (808.0) | 2,386.4 (842.7) | 2,181.8 (975.3) | 0.39 | 0.68 | ||
| Dose per kg of dosing body weight | 45.3 (18.9) | 35.1 (17.0) | 32.7 (12.9) | 34.6 (15.0) | 26.7 (12.1) | 0.01 | 0.02 |
aCrystalloid, colloid, crystalloid equivalent volume, red blood cell and fresh frozen plasma for first six hours. All others for day 1. bAdjusted for creatinine clearance. cAdjusted for creatinine clearance and pulmonary capillary wedge pressure. BMI, body mass index.