Table 1.
Patients, relapse and follow-up in women with breast cancer by use of digoxin
| Patients, number (%) | P-value1 | Relapse, number | Total person-years of follow-up | ||||
|---|---|---|---|---|---|---|---|
| Digoxin use at breast cancer | Digoxin use at breast cancer | Users of digoxin | Non-users of digoxin | ||||
| Yes | No | Yes | No | ||||
| Total | 369 (100) | 34,085 (100) | 45 | 5,061 | 1,487 | 148,418 | |
| Age, years | |||||||
| 20 to 54 | 12 (3.2) | 13,593 (39.9) | <0.001 | 2 | 2,217 | 68 | 63,050 |
| 55 to 60 | 36 (9.8) | 7,097 (20.8) | 5 | 1,059 | 165 | 31,240 | |
| 61 to 69 | 163 (44.2) | 9,764 (28.6) | 20 | 1,288 | 641 | 39,832 | |
| 70 to 74 | 158 (42.8) | 3,631 (10.7) | 18 | 497 | 614 | 14,296 | |
| Year of onset | |||||||
| 1995 to 1999 | 164 (44.4) | 10,612 (31.1) | <0.001 | 29 | 2,563 | 810 | 64,854 |
| 2000 to 2004 | 111 (30.1) | 12,250 (35.9) | 12 | 1,861 | 512 | 63,785 | |
| 2005 to 2008 | 94 (25.5) | 11,223 (32.9) | 4 | 637 | 165 | 19,779 | |
| Tumor size | |||||||
| No information | 5 (1.4) | 361 (1.1) | 0.602 | 1 | 58 | 13 | 1,653 |
| ≤2 cm | 226 (62.1) | 20,180 (59.8) | 0.653 | 22 | 2,236 | 945 | 90,817 |
| 2 to 5 cm | 127 (34.9) | 12,361 (36.7) | 19 | 2,403 | 485 | 51,454 | |
| >5 cm | 11 (3.0) | 1,183 (3.5) | 3 | 364 | 45 | 4,495 | |
| Tumor-positive nodes | |||||||
| No information | 3 (0.8) | 45 (0.1) | 0.015 | 0 | 5 | 10 | 96 |
| 0 | 216 (59.1) | 18,062 (53.1) | 0.139 | 20 | 1,865 | 912 | 82,010 |
| 1 to 3 | 97 (26.5) | 10,305 (30.3) | 8 | 1,449 | 399 | 45,639 | |
| 4 to 9 | 36 (9.8) | 3,619 (10.6) | 11 | 977 | 120 | 14,095 | |
| ≥10 | 17 (4.6) | 2,054 (6.0) | 6 | 765 | 47 | 6,578 | |
| Histology grading | |||||||
| No information | 8 (2.2) | 608 (1.8) | 0.580 | 2 | 77 | 24 | 2,899 |
| Ductal grade I | 118 (32.7) | 8,602 (25.7) | 0.004 | 13 | 926 | 495 | 40,317 |
| Ductal grade II to III | 172 (47.7) | 18,652 (55.7) | 24 | 3,199 | 605 | 76,710 | |
| Non-ductal | 71 (19.7) | 6,223 (18.6) | 6 | 859 | 363 | 28,492 | |
| Estrogen receptor | |||||||
| No information | 14 (3.8) | 1,051 (3.1) | 0.446 | 1 | 239 | 57 | 6,303 |
| Positive | 303 (85.4) | 25,956 (78.6) | 0.002 | 38 | 3,473 | 1,262 | 111,747 |
| Negative | 52 (14.6) | 7,078 (21.4) | 6 | 1,349 | 168 | 30,368 | |
1Chi2 tests for comparison of group with no information to those with information, and heterogeneity among groups within strata with known data.