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. 2013 Mar 12;15(2):R22. doi: 10.1186/bcr3398

Figure 7.

Figure 7

ATF6α and XBP1 transactivate PRNP promoter. (A) Ethidium bromide stained gel showing ΔATF6α, sXBP1 and XBP1 amplicons from HEK293 cells co-transfected with the pGL-538 PRNP promoter luciferase reporter and pCGN-ATF6α (1-373) and/or pCGN-sXBP1. (B) Luciferase luminescence generated from HEK293 cells co-transfected as described in A. (C) Ethidium bromide stained gel showing ATF6α and XBP1 amplicons from HEK293 cells co-transfected with the pGL-538 PRNP promoter luciferase reporter and siRNAs against ATF6α or XBP1. (D) Luciferase luminescence generated from HEK293 cells co-transfected as described in C. Statistical analyses on B and D were one-way ANOVA followed by a Tukey-Kramer multiple comparison test.