Table 4.
Different relation between HOMA-IR index and proinsulin metabolites in controls and patients.
| β coefficient (95% CI) | ||||
|---|---|---|---|---|
| Intact proinsulin | Intact proinsulin/ | Split proinsulin | Split proinsulin/ | |
| C-peptide ratio | C-peptide ratio | |||
| HOMA-IR index | ||||
| Controls | 4.02 (0.66-7.36) | 6.23 (1.41-11.06) | 10.95 (3.22-18.17) | 14.84 (3.99-25.70) |
| Patients | 0.97 (-0.11-2.06) | 0.43 (-0.86-1.71) | 6.98 (3.44-10.52) | 5.83 (1.40-10.25) |
| P valuea | 0.36 | 0.03 | 0.47 | 0.23 |
| RA on GC | 1.28 (-0.42-2.98) | 0.39 (-1.66-2.44) | 6.94 (3.38-10.50) | 5.37 (1.06-9.69) |
| RA non on GC | 0.74 (-0.82-2.28) | 5.55 (-1.26-2.36) | 4.95 (-1.29-11.18) | 3.70 (-4.13-11.72) |
| P valueb | 0.63 | 0.90 | 0.57 | 0.72 |
P value represents the comparison of β coefficient between controls and patients (a) and between RA on GC and RA not taking GCs (b) when interaction "HOMAIR × disease" is included in the regression model. HOMA-IR index is considered an independent variable, and proinsulin metabolites as dependent variables. Significant associations (P < 0.05) are depicted in bold