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Knockdown of PERK, ATF4 and LAMP3 reduces cell migration under hypoxic conditions in gap closure assays. (A-F) Effect of hypoxia (1% O2) in combination with transient knockdown of PERK, ATF4 or LAMP3 in MDA-MB-231 cells on cell migration in a gap closure assay. Results are from two representative experiments. ATF4, activating transcription factor 4; LAMP3, lysosomal-associated membrane protein 3; PERK, PKR-like endoplasmic reticulum kinase.
