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. 2013 Feb 22;15(1):R32. doi: 10.1186/ar4181

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Copyright © 2013 Naraoka et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Matrix metalloproteinase-13 expression during osteoarthritis development. Immunohistochemical findings for matrix metalloproteinase (MMP)-13 in the medial femoral condylar cartilage from (A) a control knee, (B) a collagen tripeptide (Ctp)-treated knee, (C) a hyaluronan (HA)-treated knee and (D) a Ctp/HA-treated knee 5 weeks after surgery (original magnification ×400). (E) Appearance of the MMP-13 (×400) staining in the medial femoral condylar cartilage from a normal rabbit knee. (F) Population of MMP-13-positive chondrocytes in medial femoral condylar cartilage of each group 5, 10 and 15 weeks after surgery. Counted area was 6.76 × 10⁴μm². Data presented as mean ± standard deviation (*P <0.05).