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. 2013 Jan 25;15(1):R20. doi: 10.1186/ar4152

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Copyright © 2013 Jones et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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RF inhibits rituximab effects by binding the Fc portion of RTX. A. Monoclonal IgM RF has an inhibitory effect on RTX-CDC when RTX (1 μg/ml) has an IgG1 heavy chain, but not when RTX has an IgG3 heavy chain (n = 3). B. Addition of RTX 10 μg/ml to PBMC in serum free media after addition of monoclonal IgM RF (n = 6) or IgA RF (n = 3) inhibits loss of CD19 by RTX-mediated trogocytosis. Inhibitory effects of RF found to be statistically significant (P < 0.05) are indicated by asterisks. Error bars represent mean standard error.