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ROC-curve analysis of the three-gene panel in control samples including age-matched healthy and benign disease controls. ROC curves were established for different biomarker combinations to determine a cutoff value. A cutoff value of 0.085% methylation was defined for positive detection of disease; the specificity of the panel increased to 80.5% with a sensitivity of 51.4%. ROC analysis revealed an area under the curve (AUC) of 0.712 (95% CI, 0.653 to 0.770).
