Table 3.

Sensitivity and specificity of serum-based detection of aberrantly methylated genes in the test set

	Sensitivity in breast cancer		Specificity in healthy controls		Specificity in benign breast diseases
Gene	Methylation positive	%	Methylation negative	%	Methylation negative	%
ITIH5	27 of 112	24	96 of 102	94	20 of 20	100
DKK3	37 of 112	33	101 of 102	99	20 of 20	100
WIF1	39 of 112	35	97 of 102	95	15 of 20	75
SFRP1	12 of 112	11	92 of 102	90	17 of 20	85
SFRP2	21 of 112	19	90 of 102	88	18 of 20	90
SFRP5	9 of 112	8	n.d.		n.d.
DKK3/ITIH5a	46 of 112	41	95 of 102	93	20 of 20	100

^aEither gene methylated. n.d., not done.