Figure 1.

Comparison of allele specific IFN-γ T cell responses to 3D7 (open circles) and FVO/Wellcome (closed triangles) AMA1 and MSP1 in volunteers at key time-points during two independent Phase Ia clinical trials of bi-allelic AMA1 and MSP1 vaccines. Graphs represent the individual response and group median for T cell responses, expressed as IFN-γ SFU/10⁶ PBMC summed from pools containing overlapping peptides from the vaccine insert. (A) AMA1 allele specific responses calculated by adding the allele specific response (3D7 or FVO) to the common pool response for each individual. MSP1₃₃ (B) and MSP1₁₉ (C) fragment specific responses for each allele (3D7 or Wellcome) calculated by adding responses from relevant peptide pools. Day 0 calculations are excluded from statistical analysis. Ratios for the two median responses are also included (>1 = stronger 3D7 response). *P = <0.05, **P = <0.01.