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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Immunol. 2013 Jan 4;190(3):1135–1147. doi: 10.4049/jimmunol.1201455

Figure 3.

Figure 3

CHMI induces allele-specific responses in unvaccinated control volunteers in a Phase IIa efficacy study. (A) The total antigen specific IFN-γ T cell response peaks 35 days post CHMI (dC+35). Peak response breakdown to individual pools for MSP1 (B) and AMA1 (C) following 3D7 challenge, calculated by subtracting baseline response before CHMI (dC-1) from response 35 days after CHMI (dC+35). Pools can be identified as containing conserved sequences (light grey), 3D7-specific sequences (white), Wellcome/FVO-specific sequences (dark grey), or FVO AMA1 C-terminal region sequences (black).