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. Author manuscript; available in PMC: 2013 Sep 15.
Published in final edited form as: Cancer Res. 2013 Jan 23;73(6):1721–1732. doi: 10.1158/0008-5472.CAN-12-2233

Figure 4.

Figure 4

Therapeutic targeting of LOX prevents fibrosis-enhanced pulmonary metastases

(A) Effects on 4T1 wt primary tumor volume by pre-induced fibrosis shows no significant changes in primary tumor growth (B) Examples of H&E staining of lung tissue showing decrease in the presence of pulmonary metastases in antibody treated fibrotic models (C) Relative quantitative analysis of total metastatic burden (% of Total Lung) shows decreases metastases in αLOX treated fibrotic lung compared to control. (Scale bars = approx 200μm).