Figure 4.

Interrelation between mitochondrial matrix Ca²⁺, cytosolic Ca²⁺, and mitochondrial matrix pH. (A) Graph showing a linear relationship between the volume average cytosolic Ca²⁺ concentration, [Ca²⁺]_i, and mitochondria matrix Ca²⁺ concentration, [Ca²⁺]_m. (B) (Left) Graph depicting the equilibrium mitochondrial matrix pH associated with different mitochondrial matrix Ca²⁺ concentrations, [Ca²⁺]_m. (Right) Plot showing differential changes in mitochondrial matrix pH associated with ∼10 μM step increase in mitochondrial matrix Ca²⁺ concentration. Error bars indicate the mean ± SE.