Figure 7.

Model for the regular stepping and slip mode of kinesin-8 dimers. The states of the regular stepping and slip pathway are connected by black and magenta lines, respectively. The two heads of kinesin are color-coded (blue and green) and nucleotide states are indicated. Weakly bound states are marked with a line between the motor domain and the microtubule. Fast slip movement is indicated by the magenta curled symbol. An assisting load force is applied to the motor. Several pathways are shown (more are possible). For hindering load forces, an analogous diagram can be drawn.